Do metabolites of polymethylcyclosiloxanes induce physiological disorders?
DOI:
https://doi.org/10.5055/jndr.2013.0007Abstract
Polydimethylcyclosiloxanes are synthetic organo-silicon compounds used in everyday products. Their degradation in humans is not completely understood. Dimethylsilanediol as the final metabolite is debatable. Silicon has never been directly monitored, even though complete mineralisation to carbon dioxide and silicon dioxide is likely. The latter one is not respirable, not degradable, and hardly soluble and is hence presumably accumulated within the human body. Chemical similarity to dimethylsulfoxide suggests that dimethylsilanediol is able to penetrate the intact skin and to pass the blood-brain barrier. Degradation within the brain could lead to increased levels of formic acid and silicon deposits visible as plaques. Intermediate and final metabolites may disturb the synthesis of citrate, succinate and fumarate. They may induce and boost also many of today’s autoimmune diseases like Alzheimer’s disease, Parkinson’s disease, systemic sclerosis, amyotrophic lateral sclerosis, primary biliary cirrhosis, obesity, and multiple sclerosis. In view of the possible impact of carbon-silicon compounds on human health, their metabolic pathways have to be unambiguously elucidated based on separate directly determined mass balances of carbon and silicon.
Keywords: Alumosilicate, Alzheimer’s disease, Blood-brain barrier, Citric acid circle, Dimethylsilanediol, Dimethylsulfoxide, Diabetes mellitus, Dopamine, Formic acid, Fumarate, Mitochondria, Obesity, Parkinson’s disease, Plaques, Primary biliary cirrhosis, Psoriasis, Sclerosis
DOI:10.5055/jndr.2013.0007
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