Topiramate increases local proinflammatory cytokine gene expression after nerve crush lesion in rats exclusively in injured nerves


  • Nurcan Üçeyler, MD University of Würzburg Department of Neurology Josef-Schneider-Str. 11 Würzburg, Bavaria 97080 +4993120124617
  • Stefan Bischofs, MD University of Würzburg Department of Neurology Josef-Schneider-Str. 11 Würzburg, Bavaria 97080 +4993120124617
  • Claudia Sommer, MD University of Würzburg Department of Neurology Josef-Schneider-Str. 11 Würzburg, Bavaria 97080 +4993120123763



Topiramate (TPM) is an anticonvulsant and putative neuroprotective drug. As some older anticonvulsants were shown to modulate cytokine expression, the authors investigated whether TPM influences injury-induced cytokine expression in the sciatic nerve and the L4/5 dorsal root ganglia (DRG) of rats. Twenty-five rats 12 and 24 hours after sciatic nerve crush lesion were investigated. Using quantitative real-time polymerase chain reaction, the gene expression of the proinflammatory cytokines tumor necrosis factor-alpha (TNF), its receptors 1 and 2 (TNFR1 and TNFR2), interleukin (IL)-, and IL-6 and the gene expression of the anti-inflammatory cytokines IL-10 and transforming growth factor-beta (TGFβ) were measured. In sciatic nerves, the gene expression of all cytokines and TNFR1 and TNFR2 peaked 12 hours after surgery except for IL-6 which had its maximum at 24 hours. The TPM effect was restricted to injured nerves: TPM increased gene expression of TNF (×3), IL-6 (×2.2), and IL-1β (×1.4), whereas decreased gene expression of IL-10 (×0.7). The authors propose that TPM influences cytokine gene expression by acting on Schwann cells in the injured nerve.

Keywords: Topiramate, Sciatic nerve crush, Proinflammatory cytokines, Anti-inflammatory cytokines



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How to Cite

Üçeyler, MD, N., Bischofs, MD, S., & Sommer, MD, C. (2013). Topiramate increases local proinflammatory cytokine gene expression after nerve crush lesion in rats exclusively in injured nerves. Journal of Neurodegeneration and Regeneration, 4(1), 37—43.