A patient-activated iontophoretic transdermal system for acute pain management with fentanyl hydrochloride: Overview and applications


  • Kevin T. Bain, PharmD, BCPS, CGP, FASCP




iontophoresis, transdermal, fentanyl, opioid analgesics, patient-controlled analgesia, noninvasive method, postoperative pain, acute pain, breakthrough pain


Opioid administration by patient-controlled analgesia (PCA) is the standard therapy for acute postoperative pain. Despite its utility in this setting, limitations of this modality do exist. Consequently, noninvasive PCA systems, including an iontophoretic transdermal system (ITS) with fentanyl hydrochloride, are under development to circumvent many of these limitations. This preprogram med, self-contained, compact, needle-free system provides pain con trol superior to that of placebo and comparable to morphine PCA in the first 24 hours after major surgical procedures. The objectives of this article are to describe the method of transdermal iontophoretic medication administration and to review the literature pertaining to the fentanyl ITS.

Author Biography

Kevin T. Bain, PharmD, BCPS, CGP, FASCP

Department of Quality Outcomes, excelleRx, Inc., an Omnicare company, Philadelphia, Pennsylvania.


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How to Cite

Bain, PharmD, BCPS, CGP, FASCP, K. T. (2006). A patient-activated iontophoretic transdermal system for acute pain management with fentanyl hydrochloride: Overview and applications. Journal of Opioid Management, 2(6), 314–324. https://doi.org/10.5055/jom.2006.0047