Providing protection to patients with chronic respiratory diseases in a toxic industrial compound scenario
DOI:
https://doi.org/10.5055/ajdm.2019.0327Keywords:
CBRN, disaster planning and response, guidelines, poisoning, mass incidents, ventilationAbstract
Background: In case of dispersion of toxic industrial compounds (TICs), patients with chronic respiratory diseases would be highly endangered, as they would be unable to use the standard-issue Chemical-Biological-Radio-Nuclear (CBRN) mask. Therefore, we defined guidelines to deliver the appropriate respiratory protection devices to this subpopulation of patients.
Methods: We used the Israel Ministry of Health Registry to analyze and define chronic respiratory disease patients, both hospitalized and at home, according to their ventilatory and supportive needs. We then identified the gaps in the current available protection measures, and performed a set of in vitro, in vivo, and human studies, aimed to validate the provided tailored solutions and to develop a flow chart and a set of guidelines to be used as requested.
Results: Chronic respiratory disease patients were subdivided into three distinct groups. We found that standard oxygen and ventilator tubes do not compromise the protection factor afforded by standard protection hoods. We further developed a CBRN filter adaptor, enabling the use of standard-issued CBRN filter with all ventilators. These experiments have led to the development of a flow chart and guidelines to allow both the Military and the Civil Health authorities distributing the most appropriate respiratory protection devices to patients with chronic respiratory diseases.
Conclusions: As TIC incidents occur mostly in fixed facilities, both local and national authorities can use our approach in preparing for such an incident.References
Hughart JL, Bashor MM: Industrial chemicals and terrorism: Human health threat analysis, mitigation and prevention. Agency for Toxic Substances and Disease Registry, US Public Health Service. Available at https://www.hsdl.org/?abstract&did=447673. Accessed July 22, 2019.
Anderson AR, Wu J: Centers for Disease Control and Prevention (CDC). Top five industries resulting in injuries from acute chemical incidents-Hazardous Substance Emergency Events Surveillance, nine states, 1999-2008. MMWR Surveill Summ. 2015; 64(Suppl 2): 47-53.
Williams BL, Magsumbol MS: Emergency preparedness among people living near US army chemical weapons sites after September 11, 2001. Am J Public Health. 2007; 97: 1601-1606.
Bennett RL: Chemical or biological terrorist attacks: an analysis of the preparedness of hospitals for managing victims affected by chemical or biological weapons of mass destruction. Int J Environ Res Public Health. 2006; 3: 67-75.
Moore DH, Alexander SM: Emergency response to a chemical warfare agent incident: domestic preparedness, first response and public health considerations. In: Somani SM Romano JK, eds. Chemical Warfare Agents: Toxicity at Low Levels. Boca Raton, Florida: CRC Press; 2001: 409-435.
Rosman Y, Eisenkraft A, Milk N, et al.: Lessons learned from the Syrian sarin attack: evaluation of a clinical syndrome through social media. Ann Intern Med. 2014; 160: 644-648.
Eisenkraft A, Falk A: Toxic inhalation injury: Management and medical treatment. In: Salem H, Katz SA, eds. Inhalational toxicology. Boca Raton, Florida: CRC Press; 2014: 357-422.
Bronstein AC: Hazardous materials epidemiology: Hazmat happens. In: Walter FG, ed. AHLS Provider Manual, 4th Ed. Tucson, Arizona: The University of Arizona; 2014: 5-22.
Rimpel LY, Boehm DE, O'Hern MR, et al.: Chemical Defense Equipment. In: Tuorinsky SD, ed. Medical aspects of chemical warfare. Textbook of military medicine. Washington DC: Office of the Surgeon General, US Army, Borden Institute, Walter Reed Army Medical Center; 2008: 559-592.
Martyny J, Glazer CG, Newman LS: Respiratory Protection. N Engl J Med. 2002; 37: 824-830.
Carson SS, Cox CE, Holmes GM, et al.: The changing epidemiology of mechanical ventilation: A population-based study. J Intensive Care Med. 2006; 21: 173-182.
Lujan M, Moreno A, Veigas C, et al.: Non-invasive home mechanical ventilation: Effectiveness and efficiency of an outpatient initiation protocol compared with the standard in-hospital model. Respir Med. 2007; 101: 1177-1182.
Lloyd-Owen SJ, Donaldson GC, Ambrosino N, et al.: Patterns of home mechanical ventilation use in Europe: Results from the Eurovent survey. Eur Respir J. 2005; 25: 1025-1031.
Health Care Resources. Jerusalem, Israel: Department of Health Information, Ministry of Health; 2002 [Hebrew].
Be?eri E, Owen S, Shachar M, et al.: Impact of adding a filter for protection from toxic inhalational compounds to the ventilation circuit of mechanically ventilated patients. Disaster and Military Medicine. 2016; 2(3):1-7.
Leger P: Noninvasive positive pressure ventilation at home. Respir Care. 1994; 39: 501-510.
Hillberg RE, Johnson DC: Noninvasive ventilation. N Engl J Med. 1997; 337: 1746-1752.
Criner GJ, Brennan K, Travaline JM, et al.: Efficacy and compliance with noninvasive positive pressure ventilation in patients with chronic respiratory failure. Chest. 1999; 116: 667-675.
Mehta S, Hill NS: Noninvasive Ventilation. Am J Respir Crit Care Med. 2001; 163: 540-577.
Howard P: Conventional indications for long-term oxygen therapy and mechanical ventilation. Monaldi Arch Chest Dis. 1999; 54: 55-57.
Wedzicha JA: Long-term oxygen therapy vs long-term ventilator assistance. Respir Care. 2000; 45: 178-185.
Benumof JL: Obstructive sleep apnea in the adult obese patient: Implications for airway management. Anesthesiol Clin North Am. 2002; 20: 789-811.
Wijkstra PJ, Lacasse Y, Guyatt GH, et al.: A meta-analysis of nocturnal noninvasive positive pressure ventilation in patients with stable COPD. Chest. 2003; 124: 337-343.
Campbell LE, Lins RR, Pappas AG, et al.: Domestic preparedness: Sarin vapor challenge and corn oil protection factor (PF) testing of the CB40 CNR full face respirator. Arsenal, Maryland: Edgewood Chemical Biological Center Aberdeen Proving Ground. 2004; Report No. A821824.
Krivoy A, Luria S, Gafnit Z, et al.: Safety of biological/chemical respiratory protection filter for patients in need of oxygen supplementation. Mil Med. 2005; 170: 1029-1031.
Be'eri E, OwenS, Beeri M, et al.: A CBRN filter can be added to the air outflow port of a ventilator to protect a home ventilated patient from inhalation of toxic industrial compounds. Disaster Medicine and Public Health Preparedness. 2018; 12(6): 739-743.
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