The effects of QuikClot Combat Gauze and Celox Rapid on hemorrhage control


  • Don Johnson, PhD
  • Michelle Johnson, DNP, CRNA



QuikClot Combat Gauze, Celox Rapid, hemorrhage control, bleeding


Objective: Compare QuikClot Combat Gauze (QCG) and Celox Rapid (CR) for initial hemostasis and over a 1-hour period.

Design: Experimental study.

Setting: Approved animal laboratory.

Subjects: Twenty-one Yorkshire swine.

Interventions: Subjects were randomly assigned to either the QCG (n = 11) or CR (n = 10) group. An arteriotomy was made in the right femoral artery with a 6-mm vascular punch. Bleeding was allowed for 45 seconds. QCG or CR was applied followed by firm pressure for 3 minutes according to Committee on Tactical Combat Casualty Care guidelines. A 10-pound weight simulating a pressure dressing was applied, and the wound was observed for 1 hour. Dressing failure was bleeding > 2 percent of blood volume.

Main outcome measures: Achievement and maintenance of hemostasis and amount of hemorrhage during observation. Odds of successful hemostasis.

Results: QCG was significantly better than CR in initial hemostasis (p = 0.049) and maintaining hemostasis over 1 hour (p = 0.020). One hundred percent of QCG subjects and 70 percent of CR subjects achieved initial hemostasis. During the 1-hour observation, one additional CR subject failed to maintain hemostasis. CR had significantly more hemorrhage than QCG during the 1-hour observation (p = 0.027). QCG had no bleeding compared to CR that had a mean of 162 ± 48 mL (standard error of mean) over 2 minutes. QCG had 15.9 times greater odds of success compared to CR over a period of 1 hour. Over the 1-hour observation time, 100 percent of QCG achieved hemostasis compared to 60 percent of CR.

Conclusions: QCG is more effective than CR.

Author Biographies

Don Johnson, PhD

Retired Col, US Army Graduate Program in Anesthesia Nursing, USAFRes, Fort Sam Houston, San Antonio, Texas

Michelle Johnson, DNP, CRNA

Nurse Anesthetist, Major, US Army Graduate Program in Anesthesia Nursing, US Army Nurse Corp, Fort Sam Houston, San Antonio, Texas


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How to Cite

Johnson, PhD, D., and M. Johnson, DNP, CRNA. “The Effects of QuikClot Combat Gauze and Celox Rapid on Hemorrhage Control”. American Journal of Disaster Medicine, vol. 14, no. 1, Jan. 2019, pp. 17-23, doi:10.5055/ajdm.2019.0312.




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