Morphine prescription to terminally ill patients with lung cancer and dyspnea: French physicians’ attitudes

Authors

  • Marc K. Bendiane, MSC
  • Patrick Peretti-Watel, PhD
  • Herve Pegliasco, MD
  • Roger Favre, PhD
  • Anne Galinier, MD
  • Jean-Marc Lapiana, MD
  • Yolande Obadia, MD

DOI:

https://doi.org/10.5055/jom.2005.0008

Keywords:

morphine, dyspnea, end-of-life care, lung cancer, France

Abstract

This study aimed to investigate factors associated with analgesic use of morphine in end-of-life care. French general practitioners (GPs) and oncologists (N = 719) were asked whether they would prescribe morphine asfirst-line therapy to patients with terminal lung cancer suffering from dyspnea associated with cough and great anxiety. Overall, 54 percent of oncologists and 40percent of GPs stated that they would prescribe morphine in the presented case. This prescriptive attitude correlated with physicians’ age, professional back-ground, communication skills, and attitude toward terminally ill patients. The findings of this study indicate that improving analgesic use of opioids in end-of-life care is not only a matter of enhancing technical skills acquired through training or experience but also a matter of improving communication and empathy between physicians and patients.

Author Biographies

Marc K. Bendiane, MSC

Regional Centre for Disease Control of South-Eastern France; National Institute for Health and Medical Research—Unit 379, Institut Paoli Calmettes, Marseille, France.

Patrick Peretti-Watel, PhD

Regional Centre for Disease Control of South-Eastern France; National Institute for Health and Medical Research—Unit 379, Institut Paoli Calmettes, Marseille, France.

Herve Pegliasco, MD

Departmental Centre of Private Health Professionals, Marseille, France.

Roger Favre, PhD

Head of the Department of Medical Oncology, Public Hospitals of Marseilles, Marseilles, France.

Anne Galinier, MD

Head of the Department of Penitentiary Care, Public Hospitals of Marseilles, Marseilles, France.

Jean-Marc Lapiana, MD

Head of La Maison (palliative care clinic), Gardanne, France.

Yolande Obadia, MD

Head of the Regional Center for Disease Control of South-Eastern France; National Institute for Health and Medical Research—Unit3 79, Marseilles, France.

References

Dudgeon DJ, Lertzman M: Dyspnea in the advanced cancer patient. JPain Symptom Manage. 1998; 16: 212-219.

O’Driscoll M, Corner J, Bailey C: The experience of breathlessness in lung cancer. Eur J Cancer Care. 1999; 8(1): 37-43.

Luce JM, Luce JA: Perspectives on care at the close of life: Management of dyspnea in patients with far-advanced lung disease. JAMA. 2001; 285(10): 1331-1337.

Silvestri GA, Sherman C, Williams T, et al.: Caring for the dying patient with lung cancer. Chest. 2002; 122: 1028-1036.

Theuws JC, Lebesque JV, Boersma LJ, et al.: Predicting pul-monary toxicity of radiation. Lung Cancer. 1997; 18(2): 33-34.

Kim ES, Lu C, Khuri FR, et al.: A phase II study of STEALTH cisplatin (SPI-77) in patients with advanced non-small cell lung cancer. Lung Cancer. 2001; 34(3): 427-432.

Kouroussis C, Mavroudis D, Kakolyris S, et al.: High incidence of pulmonary toxicity of weekly docetaxel and gemcitabine in patients with non-small cell lung cancer: Results of a dose-finding study. Lung Cancer. 2004; 44(3): 363-368.

Bernhard J, Ganz PA: Psychosocial issues in lung cancer patients (part 1). Chest. 1991; 99: 216-223.

Smith E, Hann D, Ahles T, et al.: Quality of life and dyspnea in lung cancer patients. Lung Cancer. 1997; 18(1): 205.

Chochinov HM, Tataryn D, Clinch JJ, et al.: Will to live in the terminally ill. Lancet. 1999; 354: 816-819.

Bruera E, Macmillan K, Pither J, et al: Effects of morphine on the dyspnea of terminal cancer patients. J Pain Symptom Manage. 1990; 5: 341-344.

Bruera E, MacEachern T, Ripamonti C, et al.: Subcutaneous morphine for dyspnea in cancer patients. Ann Intern Med. 1993; 119: 906-907.

Boyd KJ, Kelly M: Oral morphine as symptomatic treatment of dyspnea in patients with advanced cancer. Palliat Med. 1997; 11: 277-281.

Allard P, Lamontagne C, Bernard P, et al: How effective are supplementary doses of opioids for dyspnea in terminally ill cancer patients? A randomized continuous sequential clinical trial. J Pain Symptom Manage. 1999; 17: 256-265.

Gallagher R: An approach to dyspnea in advanced disease. Can Fam Physician. 2003; 49: 1611-1616.

Ripamonti C: Management of dyspnea in advanced cancer patients. Support Care Cancer. 1999; 7(4): 233-243.

Peretti-Watel P, Bendiane MK, Obadia Y, et al.: Disclosure of prognosis to terminally-ill patients: Attitudes and practices among French physicians. JPalliatMed. 2004 (in press).

Cleeland CS, Gonin R, Hatfield AK, et al: Pain and its treatment in outpatients with metastatic cancer. N Engl J Med. 1994; 330: 592-596.

Medina FM, Barrera RR, Morales JF, et al.: Primary lung cancer in Mexico city: A report of 1,019 cases. Lung Cancer. 1996; 14(2-3): 185-193.

Benedict S: The suffering associated with lung cancer. Cancer Nurs. 1989; 12: 34-40.

Elpern EH: Lung cancer. In Groenwald SL, Frogge MH, Goodman M, Yarbro CH (eds): Cancer Nursing: Principles and Practice (ed. 3). Sudbury, MA: Jones and Bartlett, 1993.

Kvale PA, Simoff M, Prakash UB: Lung cancer: Palliative care. Chest. 2003; 123(1 Suppl): 284S-311S.

Krishnasamy M, Corner J, Bredin M, et al.: Cancer nursing practice development: Understanding breathlessness. J Clin Nurs. 2001; 10(1): 103-8.

Larue F, Colleau SM, Fontaine A, et al.: Oncologists and primary care physicians’ attitudes toward pain control and morphine prescribing in France. Cancer. 1995; 76: 2181-2185.

Peretti-Watel P, Obadia Y, Bendiane MK, et al.: The prescription of opioid analgesics to terminal cancer patients: Impact of physicians’ general attitudes and contextual factors. Palliat Support Care. 2003; 1(4): 345-352.

Von Roenn JH, Cleeland CS, Gonin R, et al.: Physician attitudes and practice in cancer pain management: A survey from the Eastern Cooperative Oncology Group. Ann Intern Med. 1993; 119: 121-126.

Peretti-Watel P, Bendiane MK, Moatti JP: Attitudes toward palliative care, conceptions of euthanasia, and opinions about its legalisation among French physicians. Soc Sci Med. 2005 (in press).

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Published

03/01/2005

How to Cite

Bendiane, MSC, M. K., P. Peretti-Watel, PhD, H. Pegliasco, MD, R. Favre, PhD, A. Galinier, MD, J.-M. Lapiana, MD, and Y. Obadia, MD. “Morphine Prescription to Terminally Ill Patients With Lung Cancer and Dyspnea: French physicians’ Attitudes”. Journal of Opioid Management, vol. 1, no. 1, Mar. 2005, pp. 25-30, doi:10.5055/jom.2005.0008.

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