Dextropropoxyphene and the cardiovascular system: About two cases of acute poisoning with cardiac conduction abnormalities
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https://doi.org/10.5055/jom.2005.0052Keywords:
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Hawton K, Simkin S, Deeks J: Co-proxamol and suicide: A study of national mortality statistics and local non-fatal self poisonings. BMJ. 2003; 326(7397): 1006-1008.
Jonasson B, Jonasson U, Saldeen T: Suicides may be overreported and accidents underreported among fatalities due to dextropropoxyphene. J Forensic Sci. 1999; 44(2): 334-338.
Madsen PS, Strom J, Reiz S, et al.: Acute propoxyphene selfpoisoning in 222 consecutive patients. Acta Anaesthesiol Scand. 1984; 28(6): 661-665.
Staikowsky F, Theil F, Mercadier P, et al.: Change in profile of acute self drug-poisonings over a 10-year period. Hum Exp Toxicol. 2004; 23(11): 507-511.
Hartman B, Miyada DS, Pirkle H, et al.: Serum propoxyphene concentrations in a cohort of opiate addicts on long-term propoxyphene maintenance therapy. Evidence for drug tolerance in humans. J Anal Toxicol. 1988; 12(1): 25-29.
Britain Committee on Safety of Medicines news release. Available online at: http://www.mca.gov.uk/aboutagency/regframework/csm/csmhome.htm.
Amsterdam EA, Rendig SV, Henderson GL, et al.: Depression of myocardial contractile function by propoxyphene and norpropoxyphene. J Cardiovasc Pharmacol. 1981; 35(1): 129-138.
Hantson P, Evenepoel M, Ziade D, et al.: Adverse cardiac manifestations following dextropropoxyphene overdose: Can naloxone be helpful? Ann Emerg Med. 1995; 25(2): 263-266.
Holland DR, Steinberg MI: Electrophysiologic properties of propoxyphene and norpropoxyphene in canine cardiac conducting tissues and in vivo. Toxicol Appl Pharmacol. 1979; 47(1): 123-133.
Bredgaard Sorensen M, Haggmark S, Nyhman H, et al.: Circulatory shock following intravenous propoxyphene poisoning. An experimental study of cardiac function and metabolism in pentobarbital-anesthetized pigs. Acta Anaesthesiol Scand. 1985; 29(1): 130-136.
Strom J, Haggmark S, Madsen PS, et al.: The effects of naloxone on central hemodynamics and myocardial metabolism in experimental propoxyphene-induced circulatory shock. Acta Anaesthesiol Scand. 1985; 29(7): 693-697.
Whitcomb DC, Gilliam FR, Starmer CF, et al.: Marked QRS complex abnormalities and sodium channel blockage by propoxyphene reversed with lidocaïne. J Clin Invest. 1989; 84(5): 1629-1636.
Ulens C, Daenens P, Tytgat J: Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents. Cardiovasc Res. 1999; 44(3): 568-578.
Wu C, Fry CH, Henry J: The mode of action of several opioids on cardiac muscle. Exp Physiol. 1997; 82(2): 261-272.
Kienbaum P, Thurauf N, Scherbaum N, et al.: Profound increase in epinephrine concentration in plasma and cardiovascular stimulation after mu-opioid receptor blockage in opioidaddicted patients during barbiturate-induced anesthesia for acute detoxification. Anesthesiology. 1998; 88(5): 1154-1161.
Pedersen CB, Strom J, Angelo HR, et al.: Dopamine and dobutamine reduce myocardial d-propoxyphene content in experimentally intoxicated rats. Hum Exp Toxicol. 1991; 10(2): 109-112.
Krantz T, Thisted B, Strom J, et al.: Severe acute propoxyphene overdose: Plasma concentrations of propoxyphene and norpropoxyphene and the effect of dopamine on circulatory failure. Acta Anaesthesiol Scand. 1986; 30(4): 271-276.
Stork CM, Redd JT, Fine K, et al.: Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate. J Toxicol Clin Toxicol. 1995; 33(2): 179-183.
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