The parenteral opioid shortage: Causes and solutions

Hanna Hollingsworth, PharmD; Chris Herndon, PharmD, CPE

doi:10.5055/jom.2018.0434

Authors

Hanna Hollingsworth, PharmD
Chris Herndon, PharmD, CPE

DOI:

https://doi.org/10.5055/jom.2018.0434

Keywords:

Opioids, shortage, protocol, ketamine, nalbuphine, butorphanol

Abstract

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Author Biographies

Hanna Hollingsworth, PharmD

PGY-1 Pharmacy Resident, HSHS St. Elizabeth’s Hospital, St. Louis, Missouri

Chris Herndon, PharmD, CPE

Professor , Southern Illinois University–Edwardsville School of Pharmacy, Edwardsville, Illinois

References

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Section 826 of Title 21 United States Code Controlled Substances Act. Available at: https://www.deadiversion.usdoj.gov/21cfr/21usc/826.htm. Accessed February 7, 2018.

Office USGA. GAO-15-202, DRUG SHORTAGES: Better Management of the Quota Process for Controlled Substances Needed; Coordination between DEA and FDA Should Be Improved. 2015. Available at https://www.gao.gov/assets/670/668252.pdf. Accessed February 7, 2018.

Woodcock J, Wosinska M: Economic and technological drivers of generic sterile injectable drug shortages. Clin Pharmacol Ther. 2013; 93(2): 170-176. doi:10.1038/clpt.2012.220

FDA: 2017-Hospira Inc 2/14/17. Available at: https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm542587.htm. Accessed February 7, 2018.

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Beaudoin FL, Lin C, Guan W, et al.: Low-dose Ketamine Improves Pain Relief in Patients Receiving Intravenous Opioids for Acute Pain in the Emergency Department: Results of a Randomized, Double-blind, Clinical Trial. Acad Emerg Med. 2014; 21(11): 1194-1202. doi:10.1111/acem.12510

Green SM, Roback MG, Kennedy RM, et al.: Clinical practice guideline for emergency department ketamine dissociative sedation: 2011 update. Ann Emerg Med. 2011; 57(5): 449-461. doi:10.1016/j.annemergmed.2010.11.030

Pharmacist’s Letter: Equianalgesic Dosing of Opioids for Pain Management. Available at: http://pharmacistsletter.therapeuticresearch.com/pl/ArticleDD.aspx?nidchk=1&cs=&s=PL&pt=2&segment=4662&dd=280821. Published 2015. Accessed February 7, 2018.