Are physicians fully aware of the potential transgenerational and multigenerational effects of a large opioid misuse in the population?

Maurizio Coppola, MD; Raffaella Mondola, MD

doi:10.5055/jom.2018.0454

Are physicians fully aware of the potential transgenerational and multigenerational effects of a large opioid misuse in the population?

Authors

Maurizio Coppola, MD
Raffaella Mondola, MD

DOI:

https://doi.org/10.5055/jom.2018.0454

Abstract

Author Biographies

Maurizio Coppola, MD

Department of Addiction, ASL CN2, Alba, Italy

Raffaella Mondola, MD

Department of Mental Health, ASL CN1, Saluzzo, Italy

References

Albrizio M, Guaricci AC, Calamita G, et al.: Expression and immunolocalization of the mu-opioid receptor in human sperm cells. Fertil Steril. 2006; 86: 1776-1779.

Agirregoitia E, Peralta L, Mendoza R, et al.: Expression and localization of opioid receptors during the maturation of human oocytes. Reprod Biomed Online. 2012; 24: 550-557.

Nielsen DA, Yuferov V, Hamon S, et al.: Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts. Neuropsychopharmacology. 2009; 34: 867-873.

Knothe C, Doehring A, Ultsch A, et al.: Methadone induces hypermethylation of human DNA. Epigenomics. 2016; 8: 167-179.

Yohn NL, Bartolomei MS, Blendy JA: Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine. Prog Biophys Mol Biol. 2015; 118: 21-33.

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Published

07/01/2018

How to Cite

Coppola, MD, M., and R. Mondola, MD. “Are Physicians Fully Aware of the Potential Transgenerational and Multigenerational Effects of a Large Opioid Misuse in the Population?”. Journal of Opioid Management, vol. 14, no. 4, July 2018, p. 237, doi:10.5055/jom.2018.0454.