Intranasal sufentanil and its emerging clinical Applications: Beyond its role in the emergency department
DOI:
https://doi.org/10.5055/jom.2012.0133Keywords:
INTRANASAL SUFENTANIL, EMERGENCY DEPARTMENT, pain controlAbstract
Dear Editor:
I read with great interest the recent article by Stephen et al.(
For instance, in a recent study, intranasal sufentanil was rated as a better alternative than prestudy breakthrough medication in 77 percent of patients with cancer. (
1) Intranasal sufentanil is rapidly emerging as a treatment alternative in a number of other scenarios besides its role in achieving effective pain control in the emergency department. Intranasal administration is safe and provides rapid relief in patients with cancer who experience breakthrough cancer pain. The low prevalence of systemic side effects makes it an ideal option in patients with cancer.2)
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References
Stephen R, Lingenfelter E, Broadwater-Hollifield C, et al.: Intranasal sufentanil provides adequate analgesia for emergency department patients with extremity injuries. J Opioid Manag. 2012; 8: 237-241.
Good P, Jackson K, Brumley D, et al.: Intranasal sufentanil for cancer-associated breakthrough pain. Palliat Med. 2009; 23: 54-58.
Mathieu N, Cnudde N, Engelman E, et al.: Intranasal sufentanil is effective for postoperative analgesia in adults. Can J Anaesth. 2006; 53: 60-66.
Bayrak F, Gunday I, Memis D, et al.: A comparison of oral midazolam, oral tramadol, and intranasal sufentanil premedication in pediatric patients. J Opioid Manag. 2007; 3: 74-78.
Roelofse JA, Shipton EA, de la Harpe CJ, et al.: Intranasal sufentanil/midazolam versus ketamine/midazolam for analgesia/sedation in the pediatric population prior to undergoing multiple dental extractions under general anesthesia: A prospective, double-blind, randomized comparison. Anesth Prog. 2004; 51: 114-121.
Zedie N, Amory DW, Wagner BK, et al.: Comparison of intranasal midazolam and sufentanil premedication in pediatric outpatients. Clin Pharmacol Ther. 1996; 59: 341-348.
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