Effect of preoperative intravenous oxycodone on sufentanil consumption after laparoscopic radical gastrectomy

Jinguo Wang, MD, PhD; Yaowen Fu, MD, PhD; Honglan Zhou, MD, PhD; Na Wang, MD, PhD

doi:10.5055/jom.2016.0330

Authors

Jinguo Wang, MD, PhD
Yaowen Fu, MD, PhD
Honglan Zhou, MD, PhD
Na Wang, MD, PhD

DOI:

https://doi.org/10.5055/jom.2016.0330

Keywords:

oxycodone, laparoscopic gastrectomy, patient-controlled analgesia

Abstract

Objective: To investigate the effect of preoperative intravenous oxycodone on sufentanil consumption by patient-controlled intravenous analgesia (PCIA) after laparoscopic radical gastrectomy.

Methodology: Forty-six patients scheduled for laparoscopic radical gastrectomy were randomly divided into two groups: group O (n = 23) received intravenous oxycodone (0.1 mg/kg) 10 minutes before surgery over 2 minutes and group C (n = 23) received normal saline as a placebo. A standardized general anesthesia and intravenous sufentanil PCIA were applied to all patients. Postoperative sufentanil doses delivered by PCIA, rescue analgesia, Ramsay sedation scale, visual analog scale (VAS) scores at rest, the overall satisfaction, and side effects were assessed.

Results: The numbers of sufentanil doses delivered by PCIA were significantly fewer and VAS scores at rest were significantly lower in group O than in group C at various time points after operation. The overall satisfaction degree was higher in group O than in group C. The incidences of side effects were similar between the two groups.

Conclusions: Preoperative intravenous oxycodone can reduce postoperative pain and sufentanil consumption after laparoscopic radical gastrectomy without an increase of side effects.

Author Biographies

Jinguo Wang, MD, PhD

Department of Urology, The First Hospital of Jilin University, Changchun, Jilin, China

Yaowen Fu, MD, PhD

Department of Urology, The First Hospital of Jilin University, Changchun, Jilin, China

Honglan Zhou, MD, PhD

Department of Urology, The First Hospital of Jilin University, Changchun, Jilin, China

Na Wang, MD, PhD

Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin, China. The corresponding author: Na Wang. E-mail: lilyly12345@163.com

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