Effect of preoperative intravenous oxycodone on sufentanil consumption after laparoscopic radical gastrectomy


  • Jinguo Wang, MD, PhD
  • Yaowen Fu, MD, PhD
  • Honglan Zhou, MD, PhD
  • Na Wang, MD, PhD




oxycodone, laparoscopic gastrectomy, patient-controlled analgesia


Objective: To investigate the effect of preoperative intravenous oxycodone on sufentanil consumption by patient-controlled intravenous analgesia (PCIA) after laparoscopic radical gastrectomy.

Methodology: Forty-six patients scheduled for laparoscopic radical gastrectomy were randomly divided into two groups: group O (n = 23) received intravenous oxycodone (0.1 mg/kg) 10 minutes before surgery over 2 minutes and group C (n = 23) received normal saline as a placebo. A standardized general anesthesia and intravenous sufentanil PCIA were applied to all patients. Postoperative sufentanil doses delivered by PCIA, rescue analgesia, Ramsay sedation scale, visual analog scale (VAS) scores at rest, the overall satisfaction, and side effects were assessed.

Results: The numbers of sufentanil doses delivered by PCIA were significantly fewer and VAS scores at rest were significantly lower in group O than in group C at various time points after operation. The overall satisfaction degree was higher in group O than in group C. The incidences of side effects were similar between the two groups.

Conclusions: Preoperative intravenous oxycodone can reduce postoperative pain and sufentanil consumption after laparoscopic radical gastrectomy without an increase of side effects.

Author Biographies

Jinguo Wang, MD, PhD

Department of Urology, The First Hospital of Jilin University, Changchun, Jilin, China

Yaowen Fu, MD, PhD

Department of Urology, The First Hospital of Jilin University, Changchun, Jilin, China

Honglan Zhou, MD, PhD

Department of Urology, The First Hospital of Jilin University, Changchun, Jilin, China

Na Wang, MD, PhD

Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin, China. The corresponding author: Na Wang. E-mail: lilyly12345@163.com


Kelly DJ, Ahmad M, Brull SJ: Preemptive analgesia I: Physiological pathways and pharmacological modalities. Can J Anaesth. 2001; 48(10): 1000-1010.

Fanelli G, Ghisi D, Berti M, et al.: Preoperative administration of controlled-release oxycodone as a transition opioid for total intravenous anaesthesia in pain control after laparoscopic cholecystectomy. Surg Endosc. 2008; 22(10): 2220-2228.

Liu ZF, Wang XJ, Wang XC, et al.: Clinical study of preoperative analgesia for liposuction. Zhonghua Zheng Xing Wai Ke Za Zhi. 2007; 23(2): 128-129.

Wang N, Wang Y, Pang L, et al.: Effect of preemptive analgesia with intravenous oxycodone in the patients undergoing laparoscopic resection of ovarian tumor. Pak J Med Sci. 2015; 31(2): 300-303.

Sinatra RS, Sevarino FB, Paige D: Patient-controlled analgesia with sufentanil: A comparison of two different methods of administration. J Clin Anesth. 1996; 8(2): 123-129.

Ved SA, Dubois M, Carron H, et al.: Sufentanil and alfentanil pattern of consumption during patient-controlled analgesia: A comparison with morphine. Clin J Pain. 1989; 5(suppl 1): S63-S70.

Todd KH, Funk JP: The minimum clinically important difference in physician-assigned visual analog pain scores. Acad Emerg Med. 1996; 3(2): 142-146.

Todd KH: Clinical versus statistical significance in the assessment of pain relief. Ann Emerg Med. 1996; 27(4): 439-441.

Farrar JT, Portenoy RK, Berlin JA, et al.: Defining the clinically important difference in pain outcome measures. Pain. 2000; 88(3): 287-294.

Konstantatos AH, Kavnoudias H, Stegeman JR, et al.: A randomized, double-blind, placebo-controlled study of preemptive oral oxycodone with morphine patient-controlled anesthesia for postoperative pain management in patients undergoing uterine artery embolization for symptomatic uterine fibroids. Cardiovasc Intervent Radiol. 2014; 37(5): 1191-1197.

Kucharz J, Filipczak-Bryniarska I, Michalowska-Kaczmarczyk A, et al.: Use of high-dose oxycodone hydrochloride in patients with visceral and neuropathic pain. Contemp Oncol (Pozn). 2015; 19(3): 257-259.

Lalovic B, Kharasch E, Hoffer C, et al.: Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites. Clin Pharmacol Ther. 2006; 79(5): 461-749.

The instruction for oxycodone hydrochloride injection. Available at http://drugs.medlive.cn/drugref/html/18769.shtml. Accessed May 4, 2016.

Cajanus K, Kaunisto MA, Tallgren M, et al.: How much oxycodone is needed for adequate analgesia after breast cancer surgery: Effect of the OPRM1 118A>G polymorphism. J Pain. 2014; 15(12): 1248-1256.



How to Cite

Wang, MD, PhD, J., Y. Fu, MD, PhD, H. Zhou, MD, PhD, and N. Wang, MD, PhD. “Effect of Preoperative Intravenous Oxycodone on Sufentanil Consumption After Laparoscopic Radical Gastrectomy”. Journal of Opioid Management, vol. 12, no. 3, May 2016, pp. 181-5, doi:10.5055/jom.2016.0330.