Specific Pharmacology of Long-Acting, Extended-Release, and Sustained-Release Opioids for the Treatment of Chronic Nonmalignant Pain

Authors

  • Paul A. Sloan, MD
  • Mellar P. Davis, MD, FCCP
  • Pamela Gamier, RN, BSN, CHPN

DOI:

https://doi.org/10.5055/jom.2014.0230

Keywords:

long-acting opioids, opioids, extended-release opioids, sustained-release opioids, pain managment, chronic noncancer pain, chronic pain

Abstract

Opioid products, specifically long-acting (LA), extended-release (ER), and sustained-release (SR) formulations, are used for the treatment of a subset of patients with chronic noncancer pain (CNCP). This article will review the specific pharmacology and risks associated with specific LA, ER, and SR opioid formulations that have been used in the treatment of chronic pain. This article will not address the indications for, evidence for and against, or general controversy regarding the use of any form of long-term opioid therapy for the treatment of chronic nonmalignant pain (CNMP), as this has been presented in other published works.

Author Biographies

Paul A. Sloan, MD

Department of Anesthesiology, University of Kentucky Medical Center, Lexington, Kentucky

Mellar P. Davis, MD, FCCP

Department of Solid Tumor Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, Ohio

Pamela Gamier, RN, BSN, CHPN

Department of Solid Tumor Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, Ohio

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05/04/2023

How to Cite

Sloan, MD, P. A., M. P. Davis, MD, FCCP, and P. Gamier, RN, BSN, CHPN. “Specific Pharmacology of Long-Acting, Extended-Release, and Sustained-Release Opioids for the Treatment of Chronic Nonmalignant Pain”. Journal of Opioid Management, vol. 10, no. 7, May 2023, doi:10.5055/jom.2014.0230.