Observations on the effects of buprenorphine and methadone on illicit drug use

Authors

DOI:

https://doi.org/10.5055/jom.0861

Keywords:

agonistic effects, buprenorphine, methadone, urine drug testing

Abstract

Objective: To determine if the agonistic effects of buprenorphine and methadone affect drug use.

Method: Quantitative examination of urine drug concentrations of patients treated with buprenorphine and methadone.

Results: Patients on buprenorphine had less opioid and methamphetamine drug use than those on methadone.

Conclusion: Patients on buprenorphine therapy appear to use less illicit drugs.

Author Biographies

Amadeo J. Pesce, PhD

Precision Diagnostics LLC, San Diego, California

Keith Tran, BS

Precision Diagnostics LLC, San Diego, California

Kevin Krock, PhD

Precision Diagnostics LLC, San Diego, California

Agnes Cua, PhD, DABCC

Precision Diagnostics LLC, San Diego, California

Richard Thomas, PhD

Precision Diagnostics LLC, San Diego, California

References

US Department of Veterans Affairs: VA/DoD clinical practice guidelines. 2021. Available at https://www.healthquality.va.gov/guidelines/mh/sud/. Accessed April 29, 2024.

Amadeo P, Raymond S, Dennis R, et al.: Effects of a pandemic and isolation on alcohol and psychoactive medication use in a population of rehabilitation and pain patients annals of clinical & laboratory science. Ann Clin Lab Sci. 2021; 51(5): 694-697.

Krock, K, Pesce A, Ritz D, et al.: Lower cutoff for LC-MS/ MS urine drug testing indicates better patient compliance. Pain Physician. 2017; 20: E1107-E1113. DOI: https://doi.org/10.36076/ppj/2017.7.E1107

Pesce AJ, Chandler N, Ackerman G: Information technology structure for urine drug testing reports 21ST century pathology 2021 21CP-1-103.pdf. Available at 21stcenturypathology.com. Accessed April 29, 2024.

Vigezzi P, Guglielmino L, Marzorati P, et al.: Multimodal drug addiction treatment: A field comparison of methadone and buprenorphine among heroin- and cocaine-dependent patients. J Subst Abuse Treat. 2006; 31: 3-7. DOI: https://doi.org/10.1016/j.jsat.2006.03.007

Montoya ID, Gorelick DA, Preston KL, et al.: Randomized trial of buprenorphine for treatment of concurrent opiate and cocaine dependence. Clin Pharmacol Ther. 2004; 75(1): 34-48. DOI: 10.1016/j.clpt.2003.09.004. DOI: https://doi.org/10.1016/j.clpt.2003.09.004

Furo H, Wiegand T, Rani M, et al.: Association between buprenorphine dose and the urine “norbuprenorphine” to “creatinine” ratio: Revised. Subst Abuse. 2023; 17: 117822182311537. DOI: 10.1177/11782218231153748. DOI: https://doi.org/10.1177/11782218231153748

Furo H, Schwartz DG, Sullivan RW, et al.: Buprenorphine dosage and urine quantitative buprenorphine, norbuprenorphine, and creatinine levels in an office-based opioid treatment program. Subst Abuse. 2021; 15: 11782218211061749. DOI: https://doi.org/10.1177/11782218211061749

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Published

05/01/2024

How to Cite

Pesce, A. J., K. Tran, K. Krock, A. Cua, and R. Thomas. “Observations on the Effects of Buprenorphine and Methadone on Illicit Drug Use”. Journal of Opioid Management, vol. 20, no. 3, May 2024, pp. 193-5, doi:10.5055/jom.0861.

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Section

Brief Communication