High opioid dosage rapid detoxification of cancer patient in palliative care with the Raffaeli model

Maria Cristina Monterubbianesi, MD; Jenny Capuccini, MD; Isabella Ferioli, MD; Davide Tassinari, MD; Donatella Sarti, PhD; William Raffaeli, MD

doi:10.5055/jom.2012.0129

Authors

Maria Cristina Monterubbianesi, MD
Jenny Capuccini, MD
Isabella Ferioli, MD
Davide Tassinari, MD
Donatella Sarti, PhD
William Raffaeli, MD

DOI:

https://doi.org/10.5055/jom.2012.0129

Keywords:

opioid, detoxification, cancer pain, tolerance, hyperalgesia, retrospective study

Abstract

Background: Chronic opioid administration can induce adverse drug-dependent events and tolerance and/or hyperalgesia development. Opioid rotation is the treatment option in this case; however, it can expose patients to long periods of ineffectiveness and/or development of withdrawal syndrome, overdose, or adverse events. To overcome this issue, a method of rapid detoxification from opioids has been developed.

Aims: To assess feasibility and efficacy of our opioid detoxification protocol in patients affected from chronic cancer pain.

Settings/Patients: We studied 15 patients, with chronic cancer pain, who were afferent to Hospice of Rimini, Italy, were in therapy with high doses of opioid and needed opioid rotation or a therapeutic variation because of opioid toxicity, inefficacy, tolerance, or hyperalgesia. Each patient received a fixed dose of endovenous morphine and clonidine plus oral ketoprofen or ibuprofen, and oral lorazepam, if required, for at least 3 days, suspending the previous opioid therapy. We monitored withdrawal symptoms, pain intensity, type, and intensity of adverse events.

Results: Withdrawal symptoms were experienced by four (26.6 percent) patients. The average Numerical Rating Scale for pain decreased significantly (p < 0.05) from 8.3 ± 1.57 to 3.6 ± 1.4 at the end of the detoxification and to 2.4 ± 1 at the end of the rotation or therapeutic adjustment. Average duration of the detoxification was 6.86 ± 6.4 days (range 3-22).

Conclusions: The results suggested that the detoxification protocol may be effective in preventing withdrawal signs in patients needing a therapeutic change because of opioid-induced tolerance, hyperalgesia, or toxicity.

Author Biographies

Maria Cristina Monterubbianesi, MD

Pain Therapy and Pallitive Care Unit, Hospice, Infermi Hospital, Rimini, Italy

Jenny Capuccini, MD

Department of Radiotherapy Barbieri- Mazzarotto, Sant’Orsola-Malpighi Hospital, Bologna, Italy

Isabella Ferioli, MD

Pain Therapy and Pallitive Care Unit, Hospice, Infermi Hospital, Rimini, Italy

Davide Tassinari, MD

Pain Therapy and Pallitive Care Unit, Hospice, Infermi Hospital, Rimini, Italy

Donatella Sarti, PhD

Pain Therapy and Pallitive Care Unit, Hospice, Infermi Hospital, Rimini, Italy

William Raffaeli, MD

Pain Clinic, Institute for Research on Pain “Fondazione Isal,” Rimini, Italy

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