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Opioid overdose protection: An inevitable need to address an alarming epidemic

Beatrice Setnik, PhD



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Centers for Disease Control and Prevention: Drug overdose deaths in the United States continue to increase in 2015. Available at: Accessed February 15, 2017.

US Department of Health and Human Services: Food and Drug Administration. Center for Drug Evaluation and Research: Abuse-Deterrent Opioids – Evaluation and Labeling. Guidance for Industry. April 2015.

US Department of Health and Human Services: Food and Drug Administration: Fact Sheet–FDA Opioids Action Plan. Available at: Accessed February 15, 2017.

Patent PCT/US2015/014690: Abuse-Resistant Drug Formulations with Built-In Overdose Protection. Kashiv Pharma, LLC. Available at: Accessed August 3, 2017.

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Sivilotti M, Messenger DW, van Vlymen J, et al.: A comparative evaluation of capnometry versus pulse oximetry during procedural sedation and analgesia on room air. CJEM. 2010; 12(5): 397-404.

Setnik B, Cone EJ: Establishing “abuse-deterrence equivalence” for generic abuse-deterrent opioid formulations: A proposed development framework. J Opioid Manag. 2016; 12(2): 96-100.



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